Coolant, and ethylene glycol
Updated
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The packaging rule
Household substances in liquid form containing 10 percent or more by weight of ethylene glycol, packaged on or after June 1, 1974, except articles exempted by 16 CFR 1500.83, shall be packaged in accordance with 1700.15(a) and (b). That means tested child-resistant packaging.
The labeling rule
Because such products are commonly marketed, stored and used in a manner increasing the possibility of accidental ingestion, products at 10 percent or more ethylene glycol shall be labeled with the signal word "warning" and the statement "Harmful or fatal if swallowed".
A ready-to-use coolant is well over the line
Concentrate is mostly glycol and a 50/50 premix is around half, so both are far above 10 percent. The threshold only becomes an interesting question for a product built mainly on propylene glycol or on water.
Propylene glycol is a different substance
The paragraph names ethylene glycol. A formulation built on propylene glycol is answering a different question, and whether it is caught by anything else is a check to run rather than an assumption to carry over.
Child resistance here has to survive the fluid
1700.15(a) requires the special packaging to keep performing in actual contact with the substance and across the openings and closings customary for the size. A gallon jug gets opened repeatedly over a season.
And special packaging shall not be reused
1700.15(c) says so directly, which sits awkwardly beside the appeal of a refillable jug. Decide which paragraph you are under before the marketing is written.
Bittering agents are a separate matter
Many states require a bitterant in antifreeze and engine coolant, and those are state programs with their own concentrations and exemptions. That is a jurisdiction-by-jurisdiction check and it is outside the federal rules this page quotes.