Chemical Resistance 4 of 5 is a screen. It is not an answer about your formulation.
The rating was taken as compatibility
It is a five-point figure attached to a resin family. It cannot speak to a pairing of a particular drug with a particular container over a particular shelf life.
And the absorptive mode was not considered at all
Chemical resistance is about the container surviving. Sorption is about the product losing something into it, and a resistant material can still absorb.
So a preservative system was lost quietly
Which is the classic failure. The container is intact, the product looks right, and the preservative has partitioned into the wall.
The liner was left out of the chemistry
It is a contact surface. A glass jar with a foamed polyethylene liner has an inert wall and a polyolefin surface against the product.
A blank liner field was read as no liner
33 closures here are recorded as No Liner and 30 are blank. The two are not the same statement and we do not guess.
Surface to volume was ignored
A small fill in a large container loses more to the wall. Capacity here runs 15 to 237 mL, so there is room to get this wrong by choosing generously.
Glass was chosen without weighing impact
Impact Resistance 1 of 5, the only low rating in either material set. Inert and fragile is a real trade and not a free choice.
Two polypropylene jars were treated as identical
The rating attaches to the resin class. Additives, colorants and mold release differ between molders and that is where leachables come from.
And the clause was read as a materials ban
It is not. It prohibits interaction so as to alter the listed attributes beyond the official or established requirements, which is a performance test.
And the closure was chosen after the container
Which is the wrong order when the liner is a contact surface. The jar and the liner are one chemistry decision and they get made as two.
The temperature range was not read at all
It is published on 410 of the 486 rows here and it is the one field that speaks directly to paragraph (b). Skipping it is skipping the easiest answer available.
The answer is a study, with the real container
Fill, store, assay. Our data narrows the candidates and does not replace the work.
References
The Davis Pack Supply catalog, measured 19 October 2026. Our published material properties are a five-point rating on five attributes, per material class rather than per product: Chemical Resistance, Clarity, Impact Resistance, Rigidity and Scratch Resistance. For the two materials on this shelf, glass is rated Chemical Resistance 5 of 5, Clarity 5, Rigidity 5, Scratch Resistance 5 and Impact Resistance 1; polypropylene is rated Chemical Resistance 4, Clarity 5, Rigidity 5, Scratch Resistance 5 and Impact Resistance 4. Ten material classes are rated in total. These are a screening tool on a resin family and not a compatibility finding for a formulation.
21 CFR 211.94, "Drug product containers and closures". (a) "Drug product containers and closures shall not be reactive, additive, or absorptive so as to alter the safety, identity, strength, quality, or purity of the drug beyond the official or established requirements." (b) "Container closure systems shall provide adequate protection against foreseeable external factors in storage and use that can cause deterioration or contamination of the drug product." (c) "Drug product containers and closures shall be clean and, where indicated by the nature of the drug, sterilized and processed to remove pyrogenic properties to assure that they are suitable for their intended use. Such depyrogenation processes shall be validated." (d) "Standards or specifications, methods of testing, and, where indicated, methods of cleaning, sterilizing, and processing to remove pyrogenic properties shall be written and followed for drug product containers and closures." Part 211 is current good manufacturing practice for finished pharmaceuticals; compounding under section 503A of the Federal Food, Drug, and Cosmetic Act carries conditional exemptions from certain requirements including cGMP, and nothing here asserts that this section applies to any particular compounder.
law.cornell.eduThe Davis Pack Supply catalog, measured 19 October 2026. 486 rows: 106 containers and 380 closures, which are the same rows the cannabis topicals group returns. 15 to 237 mL with a median of 118. 60 PP and 46 glass. 84 jars, 17 bottles, 4 tubs and pails, 1 tube. 28 white, 26 clear, 17 natural, 13 black, 12 amber, 6 blue, 4 frosted. Necks: 18 at 70-400, 16 at 89-400, 14 each at 58-400 and 53-400, 8 at 18DIN, 7 at 43-400, 5 unrecorded. Liners on the closures: 119 heat induction seal, 51 F217, 47 pressure sensitive, 33 No Liner, 32 Plastis standard, 30 unrecorded, 27 foam, 25 PE foam, 10 Plastis pasteur, 3 polycone.
