The check, before the first fill
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One: methacrylic acid, as a percentage
More than 5 percent weight to volume in a single retail package triggers special packaging. Compute it on that basis, not weight for weight, and write the figure down rather than the conclusion.
Two: acetonitrile, as a mass per container
More than 500 mg in a single container. Concentration times fill volume, recomputed for every size, including any size added later. This is the one that gets missed.
Three: is the format the exemption, or the requirement?
A pen-like applicator holding no free liquid, emerging only through the tip under any reasonably foreseeable use, is outside the methacrylic acid requirement. A bottle is inside it. Decide this before tooling.
Four: does the fitment exist on your neck?
For a polish, shop the brush caps directly: 18-400, 18-410, 20-400 or 28-400, read as full finishes rather than diameters. For a treatment, the dropper assemblies on that shelf are already matched per neck.
Five: label it for what it is
A polish, a cuticle oil and a treatment are cosmetics with ingredients in descending order of predominance. A remover at 10 percent or more petroleum distillates carries the specified signal word and two statements.
And test the closure against the solvent, over months
Liner, brush stem, bristles and dropper bulb, with a weighed control sample. Every compatibility failure in this category is slow and none of them is visible on the filling day.
File the answers per size
Both threshold calculations, the format decision, the fitment and its finish, and the label version, for each size in the range. A size extension reopens at least the acetonitrile arithmetic, and often more.
The order matters because the format is a lever
Compute the thresholds first, because knowing you are over one of them is what makes a pen applicator or a smaller fill worth considering. Choosing the container first turns a lever into a constraint.